Animal Scientists Explore Healthy Bacteria as Replacement for Antibiotics

On a cold windy morning, Kelly Nissen feeds the cows at the Iowa State University Beef Nutrition Farm north of Ames. Far from just tossing hay, he weighs out specific rations and carefully delivers them to numbered feed bunks.

“When you’re feeding, you’re always double-checking yourself to make sure it’s going in the right lot,” Nissen says.

Kelly Nissen monitors the scale as he prepares rations for cattle at the Iowa State University Beef Nutrition Farm.

Amy Mayer/Harvest Public Media

Kelly Nissen monitors the scale as he prepares rations for cattle at the Iowa State University Beef Nutrition Farm.

These cows munch on the common mix of hay, corn and distiller’s grain, but they’re often getting a little something new, too. They test different formulas that researchers in the animal science department at Iowa State develop.  Among the goals, across livestock species, is to find ways farmers can lower their use of antibiotics that are important for human health.

The antibiotics that clear up infections and keep us healthy are becoming less effective because as they are used, some bacteria develop resistance. Those pesky ones easily share their adaption, which can infect unsuspecting humans and leave doctors struggling to cure so-called drug resistant bacteria.

Scientists say giving the drugs to farm animals is part of the problem, which is why researchers are looking into new ways to keep livestock healthy and profitable, especially the animals that become our pork chops, chicken tenders and steak.

“There are alternatives to antibiotics in feed,” says Stephanie Hansen, one of those Iowa State professors. “And that’s going to be a broad area of research here in the next 10 to 15 years.”

You may be surprised to hear that researchers are turning to something you can probably find in your fridge: healthy bacteria.

Ever read the ingredients on a cup of creamy Chobani? A good yogurt will contain several live bacteria, which can help you stay healthy by keeping your gut happy. No one’s going to feed pigs, chickens or cows Yoplait. Some researchers, though, think a bacterium commonly found in your lunchbox, Lactobacillus acidophilus, may be help keep animals healthy and lead to less dependence on drugs important for human health.

Acidophilus would have the same impact in a production livestock animal as it would in humans,” Hansen says. “Maybe it’s able to outcompete a bad bacteria for attachment in the gastrointestinal tract in the intestine, so that would be a good thing.”

In essence, beneficial bacteria can crowd out the bad ones, preventing them from making you, or a cow, sick. If they protect the animals from infection, farmers will need fewer antibiotics. The U.S. Department of Agriculture’s data suggest nearly half of chickens and about 40 percent of pigs may get antibiotics when they’re not even sick, though overall use has declined in recent years.

The more farmers reduce antibiotic use on the farm, the less likely bacteria are to adapt and become resistant to our medicines. It’s a short path from use in the barn to preserving effectiveness in the hospital. Last year, the Obama Administration announced a plan aimed at cutting down reliance on these medicines.

With veterinarians and livestock producers both now looking for other ways to bring healthy animals to market size, nutrition companies are paying attention. Iowa-based Diamond V has developed a pig feed supplement made from Lactobacillus acidophilus. Jason Frank says they got the idea from work on human nutrition.

“We’ve seen improvements in weight gains, feed conversion, food intake in young pigs,” says Frank. “But more interestingly, we’ve seen that by improving general health and performance, that those pigs are requiring fewer injectable treatments.”

That’s what they’re looking for: less need to treat with antibiotics.

“As antibiotics become more limited on their use, one, we’re going to have to make changes in how we raise animals, perhaps develop more vaccines, change our stocking densities, nutrition programs,” Frank says. “But part of that transition to new production styles is looking at these products that can improve health.”

Poultry researcher Alejandro Penaloza at Oklahoma State University has found a helpful bacteria that can survive in poultry feed. He says some large chicken producers are interested in it because it helps the birds gain weight with less feed, a benefit they used to get from antibiotics. Penaloza says his probiotic could be a good replacement.

“We cannot say that probiotics is the silver bullet to completely eliminate antibiotics,” Penaloza says. “But I am sure that they can help a lot.”

Just like many people, animals might be even healthier with some changes to their diets. And as human nutrition explores new possibilities, the animal researchers will be paying attention. There’s plenty of overlap.

“There are essential oils. There are enzymes that could be supplemented,” Hansen says. “There could be a possibility that trace minerals and vitamins could play positive roles.”

Moving beyond antibiotics on the farm will be a gradual process, but it’s getting a little inspiration from our diet trends.

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